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Accelerating the Validation of Endogenous On-Target Engagement and In Cellulo Kinetic Assessment for Covalent Inhibitors of KRASG12C in Early Drug Discovery | ACS Chemical Biology
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Structure and Catalytic Regulatory Function of Ubiquitin Specific Protease 11 N-Terminal and Ubiquitin-like Domains | Biochemistry
ASKA technology-based pull-down method reveals a suppressive effect of ASK1 on the inflammatory NOD-RIPK2 pathway in brown adipocytes | Scientific Reports
Unprotected peptide macrocyclization and stapling via a fluorine-thiol displacement reaction | Nature Communications
Crystal structure of the multifunctional paramyxovirus hemagglutinin-neuraminidase | Nature Structural & Molecular Biology
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Acetyl-CoA biosynthesis drives resistance to histone acetyltransferase inhibition | Nature Chemical Biology
Ubiquitin modifications | Cell Research
Toxins | Free Full-Text | Lonomia obliqua Envenoming and Innovative Research
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Getting in Shape: Controlling Peptide Bioactivity and Bioavailability Using Conformational Constraints | ACS Chemical Biology
Membrane Binding of Antimicrobial Peptides Is Modulated by Lipid Charge Modification | Journal of Chemical Theory and Computation
The ubiquitin system | Nature Medicine
Antibiotics | Free Full-Text | Antibiotics: Conventional Therapy and Natural Compounds with Antibacterial Activity—A Pharmaco-Toxicological Screening
IJMS | Free Full-Text | Modeling SILAC Data to Assess Protein Turnover in a Cellular Model of Diabetic Nephropathy
Ultrafast Two-Dimensional Infrared Spectroscopy Resolved a Structured Lysine 159 on the Cytoplasmic Surface of the Microbial Photoreceptor Bacteriorhodopsin | Journal of the American Chemical Society
Synthesis of Vaniprevir (MK-7009): Lactamization To Prepare a 22-Membered Macrocycle | The Journal of Organic Chemistry
Uncovering the Determinants of a Highly Perturbed Tyrosine pKa in the Active Site of Ketosteroid Isomerase | Biochemistry
IJMS | Free Full-Text | TCR Recognition of Peptide–MHC-I: Rule Makers and Breakers
Loss of MTX2 causes mandibuloacral dysplasia and links mitochondrial dysfunction to altered nuclear morphology | Nature Communications
IJMS | Free Full-Text | Potential Benefits of Dietary Plant Compounds on Normal and Tumor Brain Cells in Humans: In Silico and In Vitro Approaches
Rational Discovery of Microtubule-Stabilizing Peptides | Journal of Chemical Information and Modeling
De novo design of discrete, stable 310-helix peptide assemblies | Nature
